Residual renal function after living related kidney donation. Is it enough? an early report

The utilization of living's kidneys as renal replacement for Chronic Renal Failure [CRF] patients was debated for long time. However, the lack of renal pool in one hand and the proper employment - of modern investigatory armamentarium in another hand could justify such donation. Living related donors [LRD] are subjected to extensive non invasive investigations to assess their general fitness for donation and split renal function. The impact of uni-nephrectomy on the renal function was studied in 25 LRD. Serum Creatinine [S. Cr.] Creatinine Clearance [Cr. Cl.] and renographic clearance tests for total and split renal function and renal Volume-using ultrasound were determined before and 3 months after donation. An initial increase in s.cr was - seen in 76% of donors, but all levels are within normal range. Total kidney function by Cr. Cl. showed significant drop by 36% of the pre donated value. Remaining kidney clearance increased by 5% to 64% with an average of 34% of the pre donated 1evel as measured by Tc 99m DTPA renography. Following nephrectomy compensatory hypertrophy of the remaining kidney attributed to an increase in the renal volume of 15%. In conclusion, kidney donation from livings is safe. Cr. clearance using the chemical method is a good screening test for potential LRD and for monitoring the renal function after donation. Renographic clearance using Tc 99m DTPA is as excellent useful test for split renal function in LRD work up. Long term follow up might be needed

value of newly developed monolonal antibody in the early detection of squamous cell carcinoma of the bilharzial urinary bladder

The diagnostic accuracy of a recently developed monoclonal antibody [MoAb] which was raised to an individual cytokeratin of squamous cell carcinoma [bilharzial urinary bladder cancer] [UNME/K1] is assessed. Bladder wash outs of 122 patients who had histologic evidence of different types and grades of bladder cancer were studied using an immunocytochemical staining. The overall diagnostic accuracy using this technique was 80% in squamous cell cancer, 26% in adenocarcinoma and 0% in transitional cell cancer. Moreover, low grade squamous cell carcinoma in particular had the highest accuracy [94%]. Among non- malignant controls, this technique exhibited high specificity in 89% of cases